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In 1919 South America, a landowner's wife is desperate for a child of her own, having suffered through multiple miscarriages. She finds hope, however, in a seemingly outlandish plan: She'll pray to a mythical deity to resurrect her stillborn son. The plan works, but with the child comes something else, something evil.。本片根据Alister Maclean的小说改编而成。约翰（迈克尔·杜迪考夫饰）是个专业探险家，生性喜于接受挑战的他，决定深入亚马逊丛林寻找传闻中失落的城市。随行的是一群来自不同背景的人，每个人各有自己的理由参与这趟丛林之旅，但大家目标却是一致的---寻找失落城市中被埋没的宝藏。然而半路却杀出个程咬金，一个拿人体来做实验的纳粹医生让这趟旅程成了地狱之旅……。